glutathione prevents oxidative cell death Frontiers Controlling glutathione entry into mitochondria:

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Notably, lactylation of certain proteins aids in disease recovery and improvement (Figs

Thus, mitochondrial dysfunction generates a vicious-cycle responsible for neuronal damage, genetic mutations and metabolic stress, a situation that can lead to apoptosis (Van Houten et al., 2006

Acutely, excess ROS engages cellular defenses, such as the NRF2 pathway and integrated stress response, allowing the cell to divert resources to mitigating oxidative stress

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